Bryan Johnson has made headlines for his radical anti-ageing lifestyle, creating some global conversations about his supplement choices and diet plans. The anti-ageing guru recently went viral after responding to a tweet from an X user, adding more buzz to his lifestyle choices.
What was the tweet about?
The user wrote on X, “Hunter Biden looks better at 55 on a steady diet of Ketamine and blow than Bryan Johnson looks at 47 after micro-calibrating the air in the sleep room where he logs his boners.”
ketamine reverses biological age and depression.
— Bryan Johnson (@bryan_johnson) August 15, 2025
it might be worth trying.
blow not so much. pic.twitter.com/xlnYsdnU1e
The tweet tries to convey that despite Hunter Biden, 55, reportedly using substances like ketamine and cocaine, he somehow looks better than Bryan Johnson, who at 47 spends millions on meticulous anti-aging practices, even things like micro-calibrating the air in his sleep room and tracking his bodily functions.
What was Bryan Johnson’s response?
To the tweet, the anti-ageing influencer responded saying, “starting ketamine and blow today.” He further wrote, “Ketamine reverses biological age and depression, it might be worth trying, blow not so much.”
Johnson also quoted a peer – reviewed study and explained the use of ketamine, six ketamine infusions over 2-3 weeks showed significant improvements in various health markers.
Depression scores dropped by 50%, while overall epigenetic age decreased by 1-2 years. Other areas of improvement included system-age (reduced by 0.5 to 3 years), metabolic age (down by 2.9 years), musculoskeletal age (reduced by 2.8 years), brain age (reduced by 1.5 years), and inflammation age (down by 1.9 years).
These results suggest ketamine may have potential benefits beyond mood disorders, including age-related biomarkers.
‘I can’t believe Bryan Johnson is asking us to use Ketamine’
Netizens stated their opinion on Johnson’s tweet. A user wrote, ” I can’t believe Bryan Johnson is telling me to do ketamine. This is the best day of my life.”
Another noted, “We have been losing a lot of otherwise intelligent-seeming rich people lately. Ketamine may be implicated. It may make people stop caring about what they used to care about. Please be extremely cautious around ketamine.”
“No way Ketamine is good for your body outside of treating extreme depression. I would question whether “biological age” is a BS metric,” added another. “don’t think I’ll try this one, but thanks for the research,” wrote a netizen.
