Six stocks with returns up to 250% in 12 months begin trading on the Nasdaq 100 from today. Nasdaq has announced the results of the annual reconstitution of the Nasdaq-100 Index, which will become effective prior to market open on Monday, December 22, 2025.
The following six companies will be added to the Index: Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), Ferrovial SE (Nasdaq: FER), Insmed Incorporated (Nasdaq: INSM), Monolithic Power Systems, Inc. (Nasdaq: MPWR), Seagate Technology Holdings plc (Nasdaq: STX), Western Digital Corp. (Nasdaq: WDC).
Nasdaq-100 Index
The Nasdaq-100 Index is a globally recognized index that tracks the performance of 100 of the largest non-financial companies listed on the Nasdaq Stock Market, encompassing a diverse range of industries and sectors.
From technology and retail to healthcare, telecommunications, biotechnology, and media, these companies collectively shape the new 21st century economy. The Nasdaq-100 is reconstituted each year in December, timed to coincide with the quadruple witch expiration on the Friday of the quarter.
As of December 2025, the Nasdaq-100 Index underpins more than 200 tracking products with over $600 billion in assets under management globally, including the Invesco QQQ Trust (QQQ), which seeks to deliver investment results that, before expenses, correspond to the performance of the Nasdaq-100 Index.
In addition to QQQ, a range of derivatives and structured instruments, such as futures, options, and other products based on the Nasdaq-100 Index and the Invesco QQQ Trust, trade on various exchanges.
As a result of the reconstitution, the following six companies will be removed from the Index: Biogen Inc. (Nasdaq: BIIB), CDW Corporation (Nasdaq: CDW), GlobalFoundries Inc. (Nasdaq: GFS), Lululemon Athletica Inc. (Nasdaq: LULU), ON Semiconductor Corporation (Nasdaq: ON), The Trade Desk, Inc. (Nasdaq: TTD).
New Additions to Nasdaq 100
Alnylam Pharmaceuticals, Ferrovial, Insmed, Monolithic Power Systems, Seagate Technology and Western Digital are the six companies to start trading on Nasdaq 100 index from December 22.
Alnylam has pioneered RNA interference (RNAi) therapeutics, an innovative class of medicines that treats diseases differently – by silencing the genes that cause or contribute to them. Alnylam is up by 65% in the last 12 months.
Ferrovial is one of the largest listed infrastructure companies in North America, where it has operated for more than 20 years building and managing express lanes in Texas, North Carolina, Virginia and Ontario. Currently, the company is also developing the New Terminal One at New York’s JFK International Airport. Ferrovial is up by 58% in the last 12 months.
Insmed is a global biopharmaceutical company striving to deliver first- and best-in-class therapies to transform the lives of patients facing serious diseases. Insmed is up by 147% in the last 12 months.
Monolithic Power Systems is a leading international semiconductor company. Monolithic Power Systems (MPS) creates cutting-edge solutions to improve the quality of life with green, easy-to-use products. Monolithic Power Systems is up by 51% in the last 12 months.
Seagate Technology is a leading innovator of mass-capacity data storage, creating breakthrough technology and offering a full portfolio of storage devices, systems, and services from edge to cloud. Seagate Technology is up by 234% in the last 12 months.
Western Digital empowers the systems and people who rely on data, consistently delivering massive capacity, high quality and low TCO. Western Digital is trusted by hyperscale cloud providers, enterprise data centers, content professionals and consumers around the world. Western Digital is up by 289% in the last 12 months.