Transgene, a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, NEC Corporation and AI technologies and BostonGene Corporation, on Tuesday announced the expansion of their collaboration for the randomized Phase I/II trial of TG4050, an individualized therapeutic vaccine for patients with head and neck cancers.
BostonGene is partnering with NEC and Transgene to continue performing tumor molecular profiling and microenvironment analysis and provide high-throughput sequencing services. The partnership with BostonGene will enable fast turnaround of next-generation sequencing (NGS) data, and sophisticated analytics will enable comprehensive profiling of patient immune contexture.
TG4050, a personalized immunotherapy designed to stimulate the immune system of patients to induce a neoantigen-specific T-cell response that can recognize and destroy tumor cells, is based on Transgene’s myvac platform and powered by NEC’s AI-driven Neoantigen Prediction System.
“Our collaboration with BostonGene has provided in-depth information on patient phenotypes in the Phase I trial. It has allowed us to understand the baseline status of our patients and how the tumor micro-environment (TME) might evolve following treatment. ” said Dr. Alessandro Riva, Chairman and CEO of Transgene.
“The combined expertise of Transgene, NEC and BostonGene will continue to provide a streamlined pipeline for the timely delivery of patient-tailored vaccines as well as data to guide the future development of new personalized treatment options, elevating the standard of care for head and neck cancer patients,” said Masamitsu Kitase, Corporate SVP and Head of the Healthcare and Life Sciences Division at NEC Corporation.
“We are committed to supporting Transgene and NEC as they advance these clinical trials,” said Nathan Fowler, MD, Chief Medical Officer at BostonGene. “Our molecular and immune profiling techniques comprehensively analyze the tumor, microenvironment, and immune system to identify key predictors of response to TG4050, ultimately improving treatment outcomes.”
