The results from a new study trial reveal that combining Nicotine Replacement Therapy (NRT) with behavioural therapy increased quit rates by nearly five times compared to counselling alone. The new clinical trial conducted at SCB Dental College and Hospital in Cuttack, Odisha.
This breakthrough finding offers immense hope for the millions of smokers and smokeless tobacco users in India struggling to break free from their dependence.
The trial, led by Dr. Utkal Mohanty, MDS, ePGDEPI, Dept of Public Health Dentistry, SCB Dental College, Cuttack, and former National Consultant (Oral Health), MoHFW, Govt of India, demonstrated an unprecedented five-fold increase in quit rates among participants employing a combination of Nicotine Replacement Therapy (NRT) and behavioural intervention.
Reflecting on the outcomes, Dr. Utkal Mohanty stated, “The combination of Nicotine Replacement Therapy (NRT) and behavioural therapy demonstrated remarkable effectiveness, exhibiting nearly fivefold higher quit rates compared to counselling alone. Relying solely on individual willpower has long been the burden for quitting tobacco in India, and the trial revealed the transformative impact of a holistic approach. Integrating NRT with personalized behavioural support not only increased quit rates but also offered crucial guidance and encouragement throughout the participants’ journey. We should extend this model to ensure widespread access to comprehensive quit resources. The trial’s results, highlighting NRT’s efficacy for smokeless tobacco users, represent a landmark moment that can shape future policies on NRT accessibility.”
According to the latest data from the National Family Health Survey-5 (2019-2021), Odisha has one of the highest prevalence of tobacco use in the country, with 51.6% of men and 26% of women consuming tobacco in any form. This is higher than the national average of 38% of men and 8.9% of women. Tobacco use is a major risk factor for oral cancer, which accounts for 27% of the country’s cancer burden.
“This clinical trial is a game-changer in the fight against tobacco addiction. The remarkable success of nicotine replacement therapy (NRT) in aiding both smokers and smokeless tobacco users, combined with the extended follow-up period, highlights its true potential as a readily available and effective tool for quitting. Overcoming nicotine dependence requires support beyond the recommended 12 weeks, and this research proves that NRT can be a safe and effective bridge to lasting freedom from tobacco. We must urgently prioritize making NRT more accessible. This critical step, along with sustained behavioural support programs, can empower millions of Indians to break free from tobacco’s deadly grip and contribute to a healthier future for all,” Padma Shri Awardee and Global Public Health Expert, Dr. Chandrakant S Pandav said.
Key Highlights of Odisha Clinical Trial:
- The trial involved 93 tobacco users (smokers and chewers) who were randomly assigned to one of three groups: nicotine gum, nicotine patch, or counselling only.
- The investigators provided extended follow-up for up to 26 weeks, well beyond the recommended 12 weeks of NRT therapy.
- Combined NRT and behavioural therapy resulted in nearly 5-fold higher quit rates compared to counselling alone.
- Notably, the study documented the efficacy of the NRT approach in smokeless tobacco users, with almost 70% of trial participants being chewers.
- Integrating NRT with comprehensive cessation programs holds the key to reducing tobacco-related illnesses and deaths.
The evidence of significantly higher quit rates with the NRT and behavioural intervention approach offers hope for millions of smokers and chewers, the researchers said.
