Colts quarterback Andrew Luck is inactive and will miss his first NFL game because of a right shoulder injury.
Backup quarterback Matt Hasselbeck will make his first start since 2012 on Sunday.
The injury forced Luck into limited action at practice this week. The move also makes sense because Indianapolis can give Luck a few more days of rest before visiting Houston on Thursday.
Despite taking more hits than any quarterback in the league over the past three seasons, according to STATS, Luck never wound up on the bench because of an injury. He started 57 consecutive games including the playoffs and has led the Colts to three straight 11-win seasons, three straight playoff appearances and back-to-back division titles.