Scientists have identified 124 genes that play a major role in determining the colour of our hair, a finding that could help law enforcers predict the hair colour of a criminal from DNA evidence at the crime scene. The discovery sheds new light on our understanding of the genetic complexity underpinning variations in human pigmentation, and could advance our knowledge of conditions linked to pigmentation, such as skin, testicular, prostate and ovarian cancers. The findings, published in the journal Nature Genetics, are also relevant for forensic sciences. Although previous studies have found that a large percentage of hair colour variation is explained by heritable factors, they only identified a dozen or so hair colour genes. The new study largely explains the genetic knowledge gap.
Researchers from King’s College London in the UK and Erasmus MC University Medical Center Rotterdam in the Netherlands analysed DNA data from almost 300,000 people of European descent, together with their self-reported hair colour information. By comparing the hair colour of the group with their genetic information, stored at several million locations across the human genome, the team identified 124 genes involved in the development of hair colour, of which more than 100 were not previously known to influence pigmentation.
The scientists also demonstrated that predicting hair colour with this new genetic information is more accurate than with previously known genes. “This work will impact several fields of biology and medicine. As the largest ever genetic study on pigmentation, it will improve our understanding of diseases like melanoma, an aggressive form of skin cancer,” said Tim Spector from King’s College London. The genes that affect hair colour also affect other cancer types, while other pigment genes affect the chances of having Crohn’s and other forms of bowel disease.
“Our work helps us to understand what causes human diversity in appearance by showing how genes involved in pigmentation subtly adapted to external environments and even social interactions during our evolution,” said Spector. “We found that women have significantly fairer hair than men, which reflects how important cultural practices and sexual preferences are in shaping our genes and biology,” he said.
“Besides substantially increasing our understanding of human pigmentation genetics in general, finding these new hair colour genes is also important for further increasing the accuracy of hair colour prediction from DNA traces in future forensic applications, which can help to find unknown perpetrators of crime,” said Manfred Kayser from Erasmus MC.