New promising ovarian cancer treatment developed

By: |
London | June 3, 2017 6:37 PM

Scientists, including one of the Indian-origin, have developed a new targeted treatment for ovarian cancer that shrinks tumours without causing any side effects.

The drug kills cells by blocking a molecule called thymidylate synthase and causing irreparable DNA damage. (Source- Reuters)

Scientists, including one of the Indian-origin, have developed a new targeted treatment for ovarian cancer that shrinks tumours without causing any side effects. Researchers believe the drug, which mimics the action of the folic acid to enter cells, could hold huge promise for women with advanced ovarian cancer who have stopped responding to standard treatment. The drug kills cells by blocking a molecule called thymidylate synthase and causing irreparable DNA damage. “The results we have seen in this trial are very promising. It is rare to see such clear evidence of reproducible responses in these early stages of drug development,” said Udai Banerji, Deputy Director, Drug Development Unit at Institute of Cancer Research (ICR) in the UK.

“The beauty of this particular drug is that it is targeted to the cancer cell. This means there are fewer side- effects, making it a kinder treatment for ovarian cancer patients,” Banerji said. Ovarian cancer cells have an abnormally large number of receptors for folic acid, called alpha-folate receptors, they are particularly targeted by the treatment, while healthy cells are left alone, researchers said. They found that since the drug targets cancer cells specifically, it did not have side-effects often seen with traditional chemotherapy such as infections, diarrhoea, nerve damage and hair loss.

Also Watch:

The team tested the drug, ONX-0801, in 15 women with ovarian cancer as part of a wider phase I clinical trial. Phase I trials are run in patients who have advanced cancer as a way of testing a drug’s safety, and it is highly unusual to see major clinical responses at this stage, researchers said. They found that the drug significantly shrunk tumours in seven of the 15 ovarian cancer patients – results the researchers described as ‘exciting’ and ‘very promising.

Get live Stock Prices from BSE, NSE, US Market and latest NAV, portfolio of Mutual Funds, Check out latest IPO News, Best Performing IPOs, calculate your tax by Income Tax Calculator, know market’s Top Gainers, Top Losers & Best Equity Funds. Like us on Facebook and follow us on Twitter.

Financial Express is now on Telegram. Click here to join our channel and stay updated with the latest Biz news and updates.

Next Stories
1IMF’s Gita Gopinath praises India for its ‘stand out’ vaccine policy in fight against Covid-19
2Pfizer/BioNTech COVID-19 vaccine neutralizes Brazil variant in lab study
3Covid-19: Low testing contributed to rising infections