Researchers led by an Indian-origin scientist have found a link between persistent insomnia and increased inflammation and mortality...
Researchers led by an Indian-origin scientist have found a link between persistent insomnia and increased inflammation and mortality.
Researchers from the University of Arizona found that people who suffer from persistent insomnia are at greater risk of mortality than those who experience intermittent insomnia.
“We hypothesised that insomnia that was persistent over eight years, rather than intermittent insomnia, was associated with death independent of the effects of sedatives, opportunity for sleep (to distinguish it from sleep deprivation), and other confounding factors in a representative sample of the general adult community,” said lead investigator Sairam Parthasarathy.
“An enhanced understanding of the association between persistence of insomnia and death would inform treatment of the ‘at-risk’ population,” said Parthasarathy, associate professor of medicine at the University of Arizona College of Medicine-Tucson.
Researchers found that subjects with persistent insomnia were 58 per cent more likely to die during the study than subjects with no insomnia and that mortality was cardiovascular- rather than cancer-related.
The study also determined that serum levels of C-reactive protein (CRP), an independent risk factor for mortality, was higher in subjects with persistent insomnia.
Although subjects with intermittent insomnia appeared to be more likely to die than no-insomnia subjects, further adjustments for various confounders such as body mass index, smoking status, and regular physical activity, as well as other confounding factors, eliminated this excess risk due to intermittent insomnia.
Investigators assessed the persistence of insomnia complaints in 1,409 adult participants from the Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD).
The study commenced in 1972 with multiple follow-up surveys to 1996 and continuous mortality follow-up data to 2011 for a total of 38 years.
Blood was collected and serum samples cryopreserved at baseline in 1972 and subsequently at multiple time points.
The persistence of insomnia was assessed based upon whether insomnia was present in both the 1984-1985 and 1990-1992 surveys (persistent insomnia), in either but not both (intermittent insomnia), or in neither of the two surveys (never insomnia).
Using data from the baseline 1972-1973 survey and the 1990-1992 follow-up survey, the researchers found that serum CRP levels increased significantly only in the persistent-insomnia group.
In those subjects where CRP data was available, persistent insomnia was associated with a 58 per cent increased mortality risk.
CRP levels are themselves associated with increased mortality, but even after adjusting for that factor, the mortality risk remained at 36 per cent for subjects with persistent insomnia.
The study was published in The American Journal of Medicine.