Novel drug treatment for COVID-19 identified

By: |
October 29, 2021 5:59 PM

The researchers from the University of Kent in the UK and Goethe-University in Germany found that the drug benfooxythiamine, an inhibitor of this metabolic pathway, suppressed reproduction of SARS-CoV-2, and infected cells did not produce coronaviruses.

The researchers noted that the drug's antiviral mechanism differs from that of other potential COVID-19 drugs such as remdesivir and molnupiravir.The researchers noted that the drug's antiviral mechanism differs from that of other potential COVID-19 drugs such as remdesivir and molnupiravir.

Researchers have identified a potential new drug treatment that suppresses the reproduction of SARS-CoV-2 virus, that causes COVID-19, in infected cells.
To multiply, all viruses infect cells and reprogramme them to produce novel viruses, the researchers said.

The study, published recently in the journal Metabolites, shows that cells infected with SARS-CoV-2 can only produce novel coronaviruses when a metabolic pathway called pentose phosphate pathway is activated.

The researchers from the University of Kent in the UK and Goethe-University in Germany found that the drug benfooxythiamine, an inhibitor of this metabolic pathway, suppressed reproduction of SARS-CoV-2, and infected cells did not produce coronaviruses.

“This is a breakthrough in the research of COVID-19 treatment,” said Professor Martin Michaelis from the University of Kent.
“Since resistance development is a big problem in the treatment of viral diseases, having therapies that use different targets is very important and provides further hope for developing the most effective treatments for COVID-19,” Michaelis said.

The researchers found that benfooxythiamine also increased the antiviral activity of ‘2-deoxy-D-glucose’, another drug which modifies the host cell’s metabolism to reduce virus multiplication.

This shows that pentose phosphate pathway inhibitors like benfooxythiamine are a potential new treatment option for COVID-19, both on their own and in combination with other treatments, they said.

The researchers noted that the drug’s antiviral mechanism differs from that of other potential COVID-19 drugs such as remdesivir and molnupiravir.
They noted that viruses resistant to these drugs may, therefore, be sensitive to benfooxythiamin.

“Targeting virus-induced changes in the host cell metabolism is an attractive way to interfere specifically with the virus replication process,” Professor Jindrich Cinatl from Goethe-University added.

Get live Stock Prices from BSE, NSE, US Market and latest NAV, portfolio of Mutual Funds, Check out latest IPO News, Best Performing IPOs, calculate your tax by Income Tax Calculator, know market’s Top Gainers, Top Losers & Best Equity Funds. Like us on Facebook and follow us on Twitter.

Financial Express is now on Telegram. Click here to join our channel and stay updated with the latest Biz news and updates.

Next Stories
1Omicron: Tope asks people to follow norms, says call on Maharashtra curbs only after consulting Centre, CM
2Over 128.66 crore Covid-19 vaccine doses given so far; Mandaviya says 85% of adult population got 1st jab
3A booster shot or an additional Covid-19 vaccine: Which one is better for you? Find out