A team of researchers has identified a new treatment strategy for tumors associated with diabetes.
New research reveal a newly discovered tissue- and organ-specific mechanism that regulates blood vessel growth, and when inhibited reduced the growth of tumors in diabetic mice.
In addition to the treatment of the diabetes-related cancers, the approach may be also used to treat other diabetic complications that are associated with the increased blood vessel growth, like retinopathy or nephropathy for example.
Researcher Olga Stenina-Adognravi said that the advanced methods of measuring and regulation of the blood sugar levels resulted in deaths from diabetic coma being very rare, but the vascular complications remain an important problem that leads to mortality and loss of quality of life.
Adognravi added that developing a new organ-specific way to prevent and treat the vascular complications and cancer growth in diabetic patients is the goal of our work.
Gerald Weissmann, Editor-in-Chief of The FASEB Journal, said that this research helps understand what goes wrong with tumor blood vessels in diabetes, adding that it not only explains how high blood sugar promotes the growth of cancers, but also outlines a strategy for treating tumors in patients with diabetes.
The study is published in The FASEB Journal.