‘Genetic risk score’: Genetics may help diagnose diabetes in Indians, says study

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Published: June 12, 2020 10:31 PM

The two types follow different treatment regimes with type-1 diabetes needing lifelong insulin injections but type-2 diabetes often being managed with diet or tablet treatment, the study said.

Genetics, diabetes, Indians, India, Hyderabad, genetic risk score, type-1 diabetes, insulin, insulin injections, type-2 diabetes, diet, tablet treatment, Scientific Reports, Pune, KEM Hospital, CSIR-Centre for Cellular and Molecular Biology, CCMB, Hyderabad, University of Exeter, UKThe genetic score may be used at the time of diabetes diagnosis to help decide if someone has type-1 diabetes, according to the study the findings of which were released on Friday.

A new study has revealed that a “genetic risk score” is effective in diagnosing type-1 diabetes in Indians.

The genetic risk score is a summary measure of a set of risk-associated genetic variants.

The score may be used at the time of diabetes diagnosis to help decide if someone has type-1 diabetes, according to the study the findings of which were released on Friday.

The two types follow different treatment regimes with type-1 diabetes needing lifelong insulin injections but type-2 diabetes often being managed with diet or tablet treatment, the study said.

Misclassification of the type of diabetes may lead to sub-standard diabetes care and possible complications.

So far, the bulk of research in this field has been conducted in European populations.

A paper published in Scientific Reports said researchers have analysed whether the European risk score is effective in diagnosing type-1 diabetes in Indians.

The team which got the findings had studied people with diabetes from Pune, India.

The team analysed 262 people with type-1 diabetes, 352 people with type-2 diabetes, and 334 people without diabetes.

All were of Indian (Indo-European) ancestry.

Outcome from the Indian population was compared with those of Europeans, it said.

The study was conducted by researchers at the KEM Hospital, Pune, CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad, and University of Exeter, UK.

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