Scientists have for the first time directly connected the Aedes aegypti mosquito with transmission of the Zika virus in the Americas. The findings may help researchers to better target efforts for controlling the population of mosquitoes carrying the Zika virus, which has been linked to serious birth defects. Last year, the first Zika infections were described in Brazil, harbingers of an explosive hemispheric epidemic. As of this month, local Zika infections have been reported in 39 countries and territories in the Americas, with the epidemic spreading throughout most of northern South America and nearly all of Central America and the Caribbean. Many countries in North America and Europe have also reported hundreds of imported cases. "Because several experimental studies have suggested that A aegypti is not highly susceptible to Zika virus infection and there has been a lack of direct evidence of A aegypti infection during outbreaks, some scientists have speculated that other common tropical urban mosquitoes such as Culex quinquefasciatus could be involved," said Scott Weaver, professor at the University of Texas Medical Branch at Galveston (UTMB). "We sought to more directly investigate which mosquito is responsible for spreading Zika virus so that we can selectively tailor our mosquito control efforts to a specific mosquito species' habits," said Weaver. The signs and symptoms of Zika infection are similar to the mosquito-borne diseases chikungunya and dengue. However, near the beginning of the outbreak last year physicians in communities on the Mexico-Guatemala border reported an increase in the number of patents showing signs and symptoms thought to be different from those of chikungunya or dengue. To study this outbreak further, researchers from the Mexican National Institute of Public Health conducted a house-to-house survey to identify patients who met the World Health Organisation (WHO) case definition of Zika virus infection in several locations in the state of Chiapas. The researchers collected 119 blood samples from people suspected of Zika virus infection. Zika virus was confirmed in 21 per cent of the blood samples using a PCR-based test. No pregnant females were studied. They also gathered adult mosquitoes in and around 69 homes of suspected Zika patients using backpack aspirators, and identified Zika virus in several samples of A aegypti but not in other mosquito species. "Our study indicates that A aegypti was the principal carrier of Zika virus in the Tapachula area of Chiapas State, based on the detection of virus in several mosquito pools and the prior demonstrated transmission competence of this species of mosquito," said Weaver. "It's important to note that Zika was not found in C quinquefasciatus, another common urban tropical mosquito discussed as a potential Zika vector," he said. The findings were published in the Journal of Infectious Diseases.