Scientists from Amrita Vishwa Vidyapeetham win patent in US and Australia for their liver cancer nanomedicine | The Financial Express

Scientists from Amrita Vishwa Vidyapeetham win patent in US and Australia for their liver cancer nanomedicine

The scientists claim that they have demonstrated that the novel technology can be used for early detection of liver cirrhosis and liver tumor, early-stage image-guided treatment of liver tumor using radio-frequency ablation therapy among others.

Scientists from Amrita Vishwa Vidyapeetham win patent in US and Australia for their liver cancer nanomedicine
Amrita Vishwa Vidyapeetham (FE.com)

A team of scientists from the School of Nanosciences & Molecular Medicine at Amrita Vishwa Vidyapeetham have won a patent in the US and Australia for a novel nanomedicine that holds great promise for early detection and treatment of liver cirrhosis and liver tumor. According to a statement by the institution on Tuesday, the invention is the outcome of a research project funded by the Nanobiotechnology Taskforce of Dept. of Biotechnology.

“Dr. Shantikumar V Nair and Professor Dr Manzoor Koyakutty from Amrita School of Nanosciences & Molecular Medicine in Kochi led a team of four researchers – Dr. Anusha Ashokan, Dr Ida M Anna, Dr Vijay Harish, Dr. Badrinath Sridharan – to create a special type of nanomedicine that responds to radio wave signals sent from outside the body. Once the nanoparticles are injected into a tumor, they can be heated up using external, medically approved radio waves. Doctors can visualize the tumor using an MRI machine and burn it off in a controlled manner,” the institute said in a statement on Tuesday.

Dr. Koyakutty also said that they have engineered the nanoparticles by a process called ‘doping’ where a few hundred calcium atoms are replaced with Iron atoms. (FE.com)

The scientists claim that they have demonstrated that the novel technology can be used for early detection of liver cirrhosis and liver tumor, early-stage image-guided treatment of liver tumor using radio-frequency ablation therapy as well as labelling and tracking the movement of stem cells inside the body after stem-cell transplantation to assess how effective the therapy has been.

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“We have made a unique nanomedicine that can be used for medical imaging, combined with drug delivery. Its particles are made of synthetically prepared calcium phosphate, a biomineral present in our bones. Generally, chemically prepared inorganic nanoparticles cause safety issues when used as nanomedicines. However, as a biomineral, calcium phosphate is biocompatible and biodegradable, hence totally safe for human use,” Said Dr. Manzoor Koyakutty, Professor, Amrita Centre for Nanosciences & Molecular Medicine in a statement on Tuesday.

Dr. Koyakutty also said that they have engineered the nanoparticles by a process called ‘doping’ where a few hundred calcium atoms are replaced with Iron atoms.

Meanwhile, Dr. Shantikumar V Nair said that two critical features make the Amrita nano-medicine unique.

“Firstly, it makes the nanomedicine imageable inside our body using medical-imaging modalities such as MRI. Secondly, we can activate these nanoparticles externally using radio-frequency waves. This enables us to see the precise location of the nanomedicine particles inside the body and externally activate them when they are exactly at the site of a disease like cancer. These features are not available in any other nanomedicine available today,” she said.

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