New antibody-based therapy raises hope for Alzheimer’s treatment | The Financial Express

New antibody-based therapy raises hope for Alzheimer’s treatment

It is noteworthy that TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and it plays a crucial role in Alzheimer’s disease.

New antibody-based therapy raises hope for Alzheimer’s treatment
Reports suggest that most people with Alzheimer’s and other dementia-related diagnoses receive care at home. (File)

A team of scientists has possibly found the potential treatment for Alzheimer’s disease with a newly developed antibody. According to scientists, the agonistic antibody can reduce the amyloid pathology of Alzheimer’s disease and which makes it promising to be a potential treatment for the disease. The findings of the disease were published in the Science Translational Medicine journal on Thursday.

“Antibody-based therapy is a viable drug modality for the treatment of Alzheimer’s disease. One of the major areas of focus at the Texas Therapeutics Institute is developing technologies to deliver antibody-based therapies across the blood-brain barrier for the potential treatment of the disease,” Zhiqiang An, lead author of the study and a scientist from the University of Texas, United States.

While conducting the study, the scientists found that a tetra-variable domain antibody, targeting the triggering receptor expressed on myeloid 2 (TREM2), reduced amyloid burden, eased neuron damage, and alleviated cognitive decline in mice with Alzheimer’s disease.

While previous research has shown that TREM2 plays an important role in the pathophysiology of Alzheimer’s disease, recent findings suggest that increasing TREM2 activation could have therapeutic effects such as improved cognition.

It is noteworthy that TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and it plays a crucial role in Alzheimer’s disease. Several studies have revealed that TREM2 is essential for microglia to detect and respond to neurodegeneration cues.

ALSO READ | IIT Jodhpur scientists develop new way to diagnose Alzheimer’s disease

Get live Share Market updates and latest India News and business news on Financial Express. Download Financial Express App for latest business news.

Photos
7 Photos
Assembly Election Results 2022: BJP’s celebratory dance in Gujarat, Congress exudes confidence in Himachal – See Photos
10 Photos
Realme 10 Pro Plus launched in India: The 10-point rough cut
9 Photos
AAP sweeps away 15 year BJP reign in MCD election – Photos from celebrations