Some immune cells may aid cancer growth

Sep 06 2013, 17:42 IST
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A colorized scanning electron micrograph of cancer cells growing in tissue culture are seen. Reuters A colorized scanning electron micrograph of cancer cells growing in tissue culture are seen. Reuters
SummaryCancer stem cells are thought to be resistant to current chemotherapy and radiation treatments.

Scientists have found that some immune cells in the body help cancer thrive and these 'traitor' cells could be used as potential targets to treat the disease.

Researchers at the University of Michigan Comprehensive Cancer Center found that these immune cells, called myeloid derived suppressor cells, provide a niche where the cancer stem cells survive.

Cancer stem cells are thought to be resistant to current chemotherapy and radiation treatments, and researchers believe that killing the cancer stem cells is crucial for eliminating cancer.

At the same time that myeloid derived suppressor cells help the cancer, they also are suppressing the immune system.

"This cell and its mechanisms are not good for your body and it helps the cancer by allowing the stem cells to thrive," said senior study author Weiping Zou, Charles B de Nancrede Professor of surgery, immunology and biology at the University of Michigan Medical School.

"If we can identify a therapy that targets this, we take away the immune suppression and the support for cancer stem cells. Essentially, we kill two birds with one stone," Zou said.

The researchers believe the immune cells give the cancer cells their "stemness" - those properties that allow the cells to be so lethal - and that without this immune cell, the cancer stem cells may not efficiently progress.

The study, which was led by Tracy X Cui and Ilona Kryczek, looked at cells from the most common and lethal type of ovarian cancer, a disease in which patients often become resistant to chemotherapy, causing the cancer to return.

Targeting the immune system for cancer treatment, called immunotherapy, has been well-received with many potential therapeutics currently being tested in clinical trials for a variety of cancer types.

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