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Manchester City will bid to extend their perfect Premier League home record this season when they defend top spot against third-placed Chelsea on Monday.
City, who went top of the table with a crushing 5-1 win at Tottenham Hotspur on Wednesday, host Chelsea after Jose Mourinho's team were held 0-0 at home by West Ham United in a London derby on Wednesday.
The big clash at the Etihad, where City have scored 42 goals in 11 league wins this season, will be a prelude of the team's FA Cup fifth-round tie at the same stadium in mid-February.
Former leaders Arsenal, who dropped two points in 2-2 draw at Southampton on Tuesday and are now one behind City, face improving Crystal Palace at home on Sunday in a rarely-played derby between the two London sides.
Arsenal have lost three times against Palace in 34 matches since they first met 80 years ago and while they should beat them again as they usually do, Palace have become far more resilient since Tony Pulis became manager in November.
Palace were bottom when Pulis arrived but are now 14th, five points clear of the relegation zone after losing only one of their last four league games.
Palace striker Marouane Chamakh would like nothing more to score against the side that let him leave last year, but Arsenal have only conceded three goals in their current unbeaten nine-game run.
The Gunners will be without Mathieu Flamini, starting a four-match ban after being sent off against the Saints, but it would still be a major surprise if they did not take all three points.
Liverpool strengthened their claims for a top-four finish for the first time since 2009 when they crushed Everton 4-0 in the Merseyside derby on Tuesday and look capable of extending their unbeaten six-match run when they travel to 15th-placed West Bromwich Albion on Sunday.
England international Daniel Sturridge has returned after injury with five goals in four matches including two against Everton, while Luis Suarez, who scored a hat-trick against West Brom in a 4-1 win at Anfield in October, will be looking to inflict more damage and add to his