Testing for human papillomavirus (HPV) may be the best way to know whether a woman is at risk of developing cervical cancer in the near future, according to a new study.
Negative HPV tests provided women with more reliable assurance that they wouldn’t develop cancer or other abnormal cervical changes in the next three years, compared to traditional Pap tests, researchers report.
“Primary HPV screening might be a viable alternative to Pap screening alone,” said Julia Gage, the study’s lead author from the National Institutes of Health’s National Cancer Institute in Bethesda, Maryland.
About 12,000 U.S. women were diagnosed with cervical cancer in 2010 and about 4,000 died from the disease, according to the Centers for Disease Control and Prevention. Roughly 91 percent of cervical cancers are thought to be caused by HPV.
Pap smears, which require doctors to collect cells from the cervix to look for abnormalities, have traditionally been used to determine whether a woman is at risk of developing cancer in the near future.
In 2012, the government-backed U.S. Preventive Services Task Force recommended women between ages 21 and 65 years be screened using a Pap test every three years and said those ages 30 to 65 years could instead opt for cotesting, which is a Pap test in combination with a HPV test, every five years.
HPV is the most common sexually transmitted infection and affects both men and women. About 79 million people have the infection but most people don’t know they’re infected because symptoms are uncommon.
HPV testing also requires doctors to collect cells like they would during a Pap test but the end result is whether the woman has the virus - not abnormal cells.
“What we wanted to see is whether primary HPV screening could be a good alternative to Pap and compare it to cotesting,” Gage said.
For the new study, the researchers used data from over one million women who were between ages 30 and 64 years and screened for cervical cancer at Kaiser Permanente Northern California since 2003.
The researchers followed women who had a negative Pap or HPV test to see whether they developed cervical cancer during the next three years. They also looked at how many women developed cervical cancer in the five years following cotesting.
Overall, about 20 women out of 100,000 developed cervical cancer in the three years following a negative Pap test. That compared to 11 women out of 100,000 who developed the cancer during