When and how long a baby looks at other people’s eyes offers the earliest behavioural sign to date of whether a child is likely to develop autism, scientists are reporting.
In a study published Wednesday, researchers using eye-tracking technology found that children who were found to have autism at age 3 looked less at people’s eyes when they were babies than children who did not develop autism. But contrary to what the researchers expected, the difference was not apparent at birth. It emerged in the next few months and autism experts said that might suggest a window during which the progression toward autism can be halted or slowed.
The study, published online in the journal Nature, found that infants who later developed autism began spending less time looking at people’s eyes between 2 and 6 months of age and paid less attention to eyes as they grew older. By contrast, babies who did not develop autism looked increasingly at people’s eyes until about 9 months old, and then kept their attention to eyes fairly constant into toddlerhood.
“This paper is a major leap forward,” said Dr Lonnie Zwaigenbaum, a paediatrician and autism researcher at the University of Alberta, who was not involved in the study. “Documenting that there’s a developmental difference between 2 and 6 months is a major, major finding.”
The authors, Warren R Jones and Ami Klin, both of the Marcus Autism Center and Emory University, also found that babies who showed the steepest decline in looking at people’s eyes over time developed the most severe autism.
“Kids whose eye fixation falls off most rapidly are the ones who later on are the most socially disabled and show the most symptoms,” said Dr Jones, director of research at the autism centre. “These are the earliest known signs of social disability, and they are associated with outcome and with symptom severity. Our ultimate goal is to translate this discovery into a tool for early identification” of children with autism.
The eye-tracking differences are not something parents and paediatricians would be able to perceive without the technology and expertise of an autism clinic, Dr Jones