Arsenal F.C. and Manchester United F.C. will be out to make amends after a weekend of damaging results when they meet at The Emirates in the Premier League on Wednesday (1945 GMT).
Arsenal F.C. lost top spot in the league after a 5-1 humiliation by a rampant Liverpool F.C. at Anfield, with their previously much-praised defence being torn to shreds as they conceded four goals in the first 20 minutes.
Manager Arsene Wenger called the performance "feeble", and will be hopeful the defeat won't signal the end of Arsenal F.C.'s title hopes as they face a run of matches taking in Manchester United F.C., Tottenham Hotspur, Chelsea, Manchester City and Everton by early March.
Defender Per Mertesacker admitted the loss was a major setback, but called on Arsenal F.C. to summon the spirit they showed after December's 6-3 loss to Manchester City, when they went on to win six of their next eight matches.
"We feel very bad at the moment, disappointed with our performance right from the start," the German told the club website (www.arsenal.com).
"It was just not good enough to compete at that level. Liverpool F.C. seemed full of confidence. At the start we were eight points clear of Liverpool F.C. so we should have been more confident and more aware of the situation but that wasn't the case.
"We have the opportunity to respond quickly on Wednesday and we have to remind ourselves what we have done from Man City until now. That is at stake and to show that responsibility for ourselves and for the pride of our club."
David Moyes admitted his first season at Old Trafford had hit a new low after Manchester United F.C. conceded an injury time goal to Darren Bent salvaged a 2-2 draw for bottom club Fulham on Sunday, despite the hosts dominating possession and sending in a remarkable 81 crosses.
Manchester United F.C. are seventh, 15 points behind leaders Chelsea and nine off Liverpool in the final Champions League qualification spot, and are fast running out of time to salvage their season.
"We have to win all our games," Moyes told the club website (www.manutd.com).
"You can ask me as many times as you like but I'll keep saying that we have to win all our games. We should have won that one (against Fulham) and we needed to as well.
"We've just got to go into the next game. That's what happens, you take the team on