home match at Chelsea on Dec. 23, and cracks have been found.
"We made too many mistakes,'' Arsenal F.C. manager Arsene Wenger said. "Our strength until now was our defensive discipline but that went as the game went on.''
The prolific strike pairing of Aguero and Negredo put Manchester City F.C. 2-1 up by halftime, with Theo Walcott's goal having made it 1-1.
Fernandinho scored in the 50th, moments after Aguero went off with a calf injury only for Walcott to score again, but Arsenal F.C.'s creaking defense was breached in the final 24 minutes by Silva, Fernandinho and Toure's penalty. Per Mertesacker netted Arsenal F.C.'s other goal in injury time.
Arsenal F.C. midfielder Jack Wilshere could face disciplinary action after being pictured raising his middle finger toward Manchester City F.C. fans during the second half.
With Liverpool not playing until Sunday, Chelsea is Arsenal F.C.'s closest challenger after an unconvincing win over Palace at Stamford Bridge.
Fernando Torres scored in the 16th minute for the Blues before Joel Ward set up Marouane Chamakh to equalize for the visitors in the 29th. Six minutes later, Ramires grabbed the winner with a right-footed shot from outside the area to the top left corner.
Everton maintained its challenge for a top-four finish by scoring three goals in the final 17 minutes to see off Fulham.
Leon Osman's 18th-minute goal in his 300th league game put Everton ahead but Dimitar Berbatov equalized from the penalty spot in the 67th.
Seamus Coleman regained the home side's lead before Gareth Barry and Kevin Mirallas completed the victory.
The Newcastle-Southampton game ended with ugly scenes on the sidelines as coaches on both benches clashed in reaction to a foul on the pitch. The goalkeeping coach from each team was sent off.
Earlier, referee Mike Jones required treatment for a bloody nose after being floored by the flailing arm of Newcastle midfielder Moussa Sissoko.
Peter Whittingham scored the second-half winner for Cardiff against West Brom, which proved to be the end for coach Clarke after 18 months in charge at The Hawthorns.
On Sunday, it's: Aston Villa vs. Man United, Norwich vs. Swansea and Tottenham vs. Liverpool.