Acetaminophen in infancy again tied to asthma: study

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Summary19% of children had asthma-like symptoms by age of 3, meaning recurrent bouts of wheezing, coughing.

Babies given acetaminophen for fevers and aches may have a heightened risk of asthma symptoms in their preschool years, according to a Danish study.

The findings, published in the Journal of Allergy and Clinical Immunology, focused on 411 Danish children and add to a mixed bag of research about whether there's a link between acetaminophen - better known by the brand name Tylenol - and children's asthma risk.

Researchers found that the more acetaminophen children were given as infants, the more likely they were to develop asthma-like symptoms in early childhood.

That statistical link alone does not prove that acetaminophen causes airway trouble, according to senior researcher Hans Bisgaard, a professor of pediatrics at the University of Copenhagen.

We think it is too early to conclude a causal relationship, he told Reuters Health in an email - though he added that the findings should encourage further research into a plausible biological mechanism by which acetaminophen could promote asthma.

The study included 336 children who were followed from birth to age seven, All had mothers with asthma, which put them at increased risk for the lung disease themselves.

Overall, 19 percent of the children had asthma-like symptoms by the age of three, meaning recurrent bouts of wheezing, breathlessness or coughing.

Bisgaard's team found the risk generally went up the more often a child was given acetaminophen in the first year of life. For each doubling in the number of days a baby received the drug, there was a 28 percent increase in the risk of asthma symptoms.

The link disappeared, though, by the time the children were seven years old. At that point 14 percent of the children had asthma, and the risk was no greater for those given acetaminophen as babies.

Weeding out the specific effects of acetaminophen on asthma risk is tricky. The biggest reason is that children with asthma tend to get more severe respiratory infections.

Compared to other children, their colds may more often turn into bronchitis or pneumonia, so it would make sense that they'd be given the fever-reducing acetaminophen more often than other children would.

Bisgaard said that his team did have information on other factors,

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