The gulf between the two city clubs will be highlighted when the Premier League reaches its climax Sunday, with Manchester City F.C. set to clinch the title and Manchester United F.C. likely to miss out on European qualification for the first time since 1990.
Who wins the league out of City and Liverpool F.C., and who takes the last Europa League berth out of Tottenham and United, are two of the three outstanding issues to be resolved in the final round of matches.
The other issue is regarding which team takes the third relegation spot alongside Fulham and Cardiff - and that is almost guaranteed to be Norwich, which is three points behind West Bromwich Albion and with a far inferior goal difference.
Here are five things to know about Sunday's Premier League finale, when all 10 matches are played at the same time:
CITY ON BRINK
Two years ago, City put its fans through the wringer on the final day of the season before clinching the title on goal difference thanks to two goals in injury time to beat Queens Park Rangers at home.
It should be more routine this time around.
City realistically needs only a point at home against 12th-place West Ham to finish at the top, as the team is two points ahead of Liverpool and holding a goal difference 13 better than its title rival.
It would require a huge meltdown for City captain Vincent Kompany not to be holding the Premier League trophy aloft for the second time in three years - City has beaten West Ham three times this season already, with their one meeting at Etihad Stadium ending 6-0.
The experience of two years ago should serve City well.
For the English championship trophy to return to Anfield for the first time in 24 years, Liverpool must beat Newcastle at home and hope for a huge favor from West Ham.
It's unlikely, but stranger things have happened. And doesn't Liverpool know it.
In 1989, Liverpool - at the time the biggest team in England - had to avoid losing by two goals or more to Arsenal at Anfield in the final game of the season to capture the league at the expense of the London club. In the most dramatic finish to an English league season, at least until two years ago, Arsenal scored in injury time through