1. Potential biomarker for pre-diabetes discovered

Potential biomarker for pre-diabetes discovered

Researchers have identified a biomarker in pre-diabetic individuals that could help prevent them from developing Type 2 diabetes.

By: | Published: August 22, 2015 7:40 AM

Researchers have identified a biomarker in pre-diabetic individuals that could help prevent them from developing Type 2 diabetes.

The researchers discovered that pre-diabetic people who were considered to be insulin resistant – unable to respond to the hormone insulin effectively – also had altered mitochondrial DNA.

Researchers made the connection by analysing blood samples taken from 40 participants enrolled in the diaBEAT-it programme, a long-term study run by multiple researchers in the Fralin Translational Obesity Research Center at Virginia Tech, US.

Participants did not have diabetes or cardiovascular disease, but were pre-diabetic and showed signs of insulin resistance.

Blood samples showed that participants had lower amounts of mitochondrial DNA with a higher amount of methylation – a process that can change the expression of genes and mitochondrial copy numbers in cells – than healthy people.

Mitochondrion is responsible for converting chemical energy from food into energy that cells can use.

“If the body is insulin resistant, or unable to respond properly to insulin, it could affect a person’s mitochondrial function and overall energy levels,” said Zhiyong Cheng, an assistant professor of human, nutrition, foods, and exercise in the College of Agriculture and Life Sciences at Virginia Tech and a Fralin Life Science Institute affiliate.

“Mitochondrial alterations have previously been observed in obese individuals, but this is the first time we’ve made the molecular link between insulin resistance and mitochondrial DNA changes,” Cheng said.

Cheng and collaborator Fabio Almeida, an assistant professor of human nutrition, foods and exercise in the College of Agriculture and Life Sciences at Virginia Tech and a Fralin Life Science Institute affiliate, believe this link could be important for treating pre-diabetic individuals to prevent Type 2 Diabetes.

“There is no known cure for Type 2 diabetes, and early diagnosis and intervention is critical to prevent this disease,” said Almeida.

“Discovery of the biomarker in obese, pre-diabetic individuals advances our understanding of how diabetes develops and provides evidence important for future diagnosis and intervention,” Almeida said.

The study was published in the journal Clinical Epigenetics.

  1. Rebecca Torres
    Aug 22, 2015 at 7:25 pm
    How to prevent the pre-diabetes? I was diagnosed with type 2 Diabetes and put on Metformin on June 26th, 2014. I started the ADA diet and followed it 100% for a few weeks and could not get my blood sugar to go below 140. Finally i began to panic and called my doctor, he told me to get used to it. He said I would be on metformin my w life and eventually insulin. At that point i knew something wasn't right and began to do a lot of research. On April 13th I found this book on . I read the book from end to end that night because everything the writer was saying made absolute sense. I started the diet that day and the next morning my blood sugar was down to 100, the next day was in the 90's and now i have a fasting blood sugar between Mid 70's and the 80's. My doctor took me off the metformin after just one week of being on this lifestyle change. I have lost over 30 pounds in a month. I now work out twice a day and still have tons of energy. I have lost 6 inches around my waist and I am off my high blood pressure medication too. I have about 20 more pounds to go till my body finds its ideal weight. The great news is, this is a lifestyle I can live with, it makes sense and it works. God Bless the writer. I wish the ADA would stop enabling consumers and tell them the truth. You can get off the drugs, you can help yourself, but you have to have a correct lifestyle and diet. No more processed foods.
    Reply
    1. Rebecca Torres
      Aug 22, 2015 at 7:37 pm
      I was diagnosed with type 2 Diabetes and put on Metformin on June 26th, 2014. I started the ADA diet and followed it 100% for a few weeks and could not get my blood sugar to go below 140. Finally i began to panic and called my doctor, he told me to get used to it. He said I would be on metformin my w life and eventually insulin. At that point i knew something wasn't right and began to do a lot of research. On April 13th I found this book on google wje592
      Reply
      1. Rebecca Torres
        Aug 22, 2015 at 7:29 pm
        I was diagnosed with type 2 Diabetes and put on Metformin on June 26th, 2014. I started the ADA diet and followed it 100% for a few weeks and could not get my blood sugar to go below 140. Finally i began to panic and called my doctor, he told me to get used to it. He said I would be on metformin my w life and eventually insulin. At that point i knew something wasn't right and began to do a lot of research. On April 13th I found this book on ( dot com/diabetes-destroyer-review/ ). I read the book from end to end that night because everything the writer was saying made absolute sense. I started the diet that day and the next morning my blood sugar was down to 100, the next day was in the 90's and now i have a fasting blood sugar between Mid 70's and the 80's. My doctor took me off the metformin after just one week of being on this lifestyle change. I have lost over 30 pounds in a month. I now work out twice a day and still have tons of energy. I have lost 6 inches around my waist and I am off my high blood pressure medication too. I have about 20 more pounds to go till my body finds its ideal weight. The great news is, this is a lifestyle I can live with, it makes sense and it works. God Bless the writer. I wish the ADA would stop enabling consumers and tell them the truth. You can get off the drugs, you can help yourself, but you have to have a correct lifestyle and diet. No more processed foods.
        Reply
        1. Rebecca Torres
          Aug 22, 2015 at 7:36 pm
          I was diagnosed with type 2 Diabetes and put on Metformin on June 26th, 2014. I started the ADA diet and followed it 100% for a few weeks and could not get my blood sugar to go below 140. Finally i began to panic and called my doctor, he told me to get used to it. He said I would be on metformin my w life and eventually insulin. At that point i knew something wasn't right and began to do a lot of research. On April 13th I found this book on (google "wje592" ). I read the book from end to end that night because everything the writer was saying made absolute sense. I started the diet that day and the next morning my blood sugar was down to 100, the next day was in the 90's and now i have a fasting blood sugar between Mid 70's and the 80's. My doctor took me off the metformin after just one week of being on this lifestyle change. I have lost over 30 pounds in a month. I now work out twice a day and still have tons of energy. I have lost 6 inches around my waist and I am off my high blood pressure medication too. I have about 20 more pounds to go till my body finds its ideal weight. The great news is, this is a lifestyle I can live with, it makes sense and it works. God Bless the writer. I wish the ADA would stop enabling consumers and tell them the truth. You can get off the drugs, you can help yourself, but you have to have a correct lifestyle and diet. No more processed foods.
          Reply
          1. Rebecca Torres
            Aug 22, 2015 at 7:37 pm
            I was diagnosed with type 2 Diabetes and put on Metformin on June 26th, 2014. I started the ADA diet and followed it 100% for a few weeks and could not get my blood sugar to go below 140. Finally i began to panic and called my doctor, he told me to get used to it. He said I would be on metformin my w life and eventually insulin. At that point i knew something wasn't right and began to do a lot of research. On April 13th I found this book on (google wje592). I read the book from end to end that night because everything the writer was saying made absolute sense. I started the diet that day and the next morning my blood sugar was down to 100, the next day was in the 90's and now i have a fasting blood sugar between Mid 70's and the 80's. My doctor took me off the metformin after just one week of being on this lifestyle change. I have lost over 30 pounds in a month. I now work out twice a day and still have tons of energy. I have lost 6 inches around my waist and I am off my high blood pressure medication too. I have about 20 more pounds to go till my body finds its ideal weight. The great news is, this is a lifestyle I can live with, it makes sense and it works. God Bless the writer. I wish the ADA would stop enabling consumers and tell them the truth. You can get off the drugs, you can help yourself, but you have to have a correct lifestyle and diet. No more processed foods.
            Reply
            1. Rebecca Torres
              Aug 22, 2015 at 7:18 pm
              I was diagnosed with type 2 Diabetes and put on Metformin on June 26th, 2014. I started the ADA diet and followed it 100% for a few weeks and could not get my blood sugar to go below 140. Finally i began to panic and called my doctor, he told me to get used to it. He said I would be on metformin my w life and eventually insulin. At that point i knew something wasn't right and began to do a lot of research. On April 13th I found this book on . I read the book from end to end that night because everything the writer was saying made absolute sense. I started the diet that day and the next morning my blood sugar was down to 100, the next day was in the 90's and now i have a fasting blood sugar between Mid 70's and the 80's. My doctor took me off the metformin after just one week of being on this lifestyle change. I have lost over 30 pounds in a month. I now work out twice a day and still have tons of energy. I have lost 6 inches around my waist and I am off my high blood pressure medication too. I have about 20 more pounds to go till my body finds its ideal weight. The great news is, this is a lifestyle I can live with, it makes sense and it works. God Bless the writer. I wish the ADA would stop enabling consumers and tell them the truth. You can get off the drugs, you can help yourself, but you have to have a correct lifestyle and diet. No more processed foods.
              Reply
              1. Rebecca Torres
                Aug 22, 2015 at 7:26 pm
                I was diagnosed with type 2 Diabetes and put on Metformin on June 26th, 2014. I started the ADA diet and followed it 100% for a few weeks and could not get my blood sugar to go below 140. Finally i began to panic and called my doctor, he told me to get used to it. He said I would be on metformin my w life and eventually insulin. At that point i knew something wasn't right and began to do a lot of research. On April 13th I found this book on natural-diabetestreatment/diabetes-destroyer-review/. I read the book from end to end that night because everything the writer was saying made absolute sense. I started the diet that day and the next morning my blood sugar was down to 100, the next day was in the 90's and now i have a fasting blood sugar between Mid 70's and the 80's. My doctor took me off the metformin after just one week of being on this lifestyle change. I have lost over 30 pounds in a month. I now work out twice a day and still have tons of energy. I have lost 6 inches around my waist and I am off my high blood pressure medication too. I have about 20 more pounds to go till my body finds its ideal weight. The great news is, this is a lifestyle I can live with, it makes sense and it works. God Bless the writer. I wish the ADA would stop enabling consumers and tell them the truth. You can get off the drugs, you can help yourself, but you have to have a correct lifestyle and diet. No more processed foods.
                Reply
                1. Rebecca Torres
                  Aug 22, 2015 at 7:28 pm
                  I was diagnosed with type 2 Diabetes and put on Metformin on June 26th, 2014. I started the ADA diet and followed it 100% for a few weeks and could not get my blood sugar to go below 140. Finally i began to panic and called my doctor, he told me to get used to it. He said I would be on metformin my w life and eventually insulin. At that point i knew something wasn't right and began to do a lot of research. On April 13th I found this book on w�j�e�5�9�2�.c�o�m/i-am-finally-free-of-diabetes/. I read the book from end to end that night because everything the writer was saying made absolute sense. I started the diet that day and the next morning my blood sugar was down to 100, the next day was in the 90's and now i have a fasting blood sugar between Mid 70's and the 80's. My doctor took me off the metformin after just one week of being on this lifestyle change. I have lost over 30 pounds in a month. I now work out twice a day and still have tons of energy. I have lost 6 inches around my waist and I am off my high blood pressure medication too. I have about 20 more pounds to go till my body finds its ideal weight. The great news is, this is a lifestyle I can live with, it makes sense and it works. God Bless the writer. I wish the ADA would stop enabling consumers and tell them the truth. You can get off the drugs, you can help yourself, but you have to have a correct lifestyle and diet. No more processed foods.
                  Reply
                  1. Rebecca Torres
                    Aug 22, 2015 at 7:28 pm
                    I was diagnosed with type 2 Diabetes and put on Metformin on June 26th, 2014. I started the ADA diet and followed it 100% for a few weeks and could not get my blood sugar to go below 140. Finally i began to panic and called my doctor, he told me to get used to it. He said I would be on metformin my w life and eventually insulin. At that point i knew something wasn't right and began to do a lot of research. On April 13th I found this book on w�j�e�5�9�2�.�c�o�m . I read the book from end to end that night because everything the writer was saying made absolute sense. I started the diet that day and the next morning my blood sugar was down to 100, the next day was in the 90's and now i have a fasting blood sugar between Mid 70's and the 80's. My doctor took me off the metformin after just one week of being on this lifestyle change. I have lost over 30 pounds in a month. I now work out twice a day and still have tons of energy. I have lost 6 inches around my waist and I am off my high blood pressure medication too. I have about 20 more pounds to go till my body finds its ideal weight. The great news is, this is a lifestyle I can live with, it makes sense and it works. God Bless the writer. I wish the ADA would stop enabling consumers and tell them the truth. You can get off the drugs, you can help yourself, but you have to have a correct lifestyle and diet. No more processed foods.
                    Reply
                    1. Rebecca Torres
                      Aug 22, 2015 at 7:29 pm
                      Really great article for me with a pre-diabetes
                      Reply
                      1. Rebecca Torres
                        Aug 22, 2015 at 7:23 pm
                        What's the potential biomarker?
                        Reply
                        1. Rebecca Torres
                          Aug 22, 2015 at 7:36 pm
                          google wje592
                          Reply
                          1. Load More Comments

                          Go to Top