1. Obesity-related inflammation may trigger type 2 diabetes

Obesity-related inflammation may trigger type 2 diabetes

Medical researchers have identified a new molecular mechanism which may play a role in development of type 2 diabetes.

By: | Published: July 31, 2015 12:51 PM

Medical researchers have identified a new molecular mechanism which may play a role in development of type 2 diabetes.

New research from Harvard T.H. Chan School of Public Health describes a surprising connection between inflammation and endoplasmic reticulum (ER) dysfunction which are known to be involved in the development of type 2 diabetes and suggests that targeting this connection could aid in the development of new therapies for the metabolic disease.

ER function is critical for the liver and other organs to maintain proper glucose levels in the body.

The researchers studied liver cells to demonstrate that obesity-associated inflammation can lead to increased production of nitric oxide (NO), a powerful gas that can cripple the ER, a mini-organ inside cells that plays a key role in the synthesis of many proteins and lipids.

Senior author Gokhan S. Hotamisligil said that the results established that in an environment suffering from chronic inflammation, mini organs lose their vitality through a specific link that was identified in their study, and suggested that therapies that target inflammatory pathways, including nitric oxide production, could be effective strategies in the treatment of metabolic disease.

In the presence of obesity, the ER is unable to initiate a cascade of intracellular events called the unfolded protein response (UPR), which relieves ER stress and restores function. The new study states that the sequence might be the opposite, it is obesity-related inflammation that impairs the UPR response and thus ER function.

In an innovative approach, the researchers engineered a form of IRE1 that could not be modified by NO, and found that it protected against the detrimental consequences of inflammation and improved metabolic control in obese mice.

The study is published in the journal Science.

  1. L
    Lillian
    Jul 31, 2015 at 5:53 pm
    Obesity has a lot of side-effects and sure enough your diet has effect on blood sugar levels. In order to lead a healthy lifestyle, having a proper diet is very important. When i was obese I was suffering from many other health problems as well but since losing 22 pounds I have become more fit. I was following the diet of lisa plog and have managed to lose 22 pounds with that diet. Google for "lisa plog diet plans"and you would be able to find her diet. it is important that you continuously follow a diet if you really want to stay fit.
    Reply

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