The IT major's scrip ended the day at Rs 2,381.10, down 0.84 per cent on the BSE. In intra-day, it fell by 1 per cent to Rs 2,376.05.
At the NSE, TCS shares lost 0.91 per cent to Rs 2,379.95.
Marketmen said the negative bias in the stock was due to profit-booking by investors ahead of TCS's result.
On the other hand, other IT biggies like Infosys and Wipro ended with gains, up 0.43 per cent and 0.45 per cent, respectively.
Meanwhile, the broader market ended on a flat note, with the BSE benchmark Sensex rising 11.44 points to settle at 25,561.16.