Together with Professor Trond Ulven from the same department and colleagues from University of Glasgow he is the co-author of a new paper on the subject in The Journal of Biological Chemistry."We want to find a way to activate this protein, because that may help us to develop a drug against obesity or diabetes," said Shimpukade. Molecules can activate proteins, so the job is 'just' to find the right molecule."But there is almost an infinite number of possible molecules that we can synthesise, and it is extremely time consuming to test molecules randomly for their possible ability to activate this particular protein," said Shimpukade.The job could therefore take years and years of painstaking experiments in laboratories but this can now be avoided thanks to the new development by the research team
"We have developed a computer model of FFA4 that can helpus to select the correct molecules for synthesis by firsttesting if they bind in the computer model," said Shimpukade."This way we can test thousands of molecules in a very short time before going into the laboratory. This will speed up the process of finding the right compounds that can be developed to efficient drugs against obesity or diabetes," he said.