Karan, 42, took to Twitter to confirm about the same. The leading lady of the film is yet to be announced.
"'Shhuddhi' will star Salman Khan and will release Diwali 2016," Karan tweeted.
Hrithik Roshan and Kareena Kapoor were initially slated to do the movie, to be directed by 'Agneepath' helmer Karan Malhotra but the project kept getting delayed.
Roshan finally decided to quit the project due to health issues and Kareena too opted out.
There were reports that Ranveer Singh and Deepika Padukone may replace them but Karan later denied the news.
Salman is currently busy with 'Kick' promotions and will start shooting Sooraj Barjatya's film next.
It is for the second time that Johar has teamed up with Salman after his 1998 debut 'Kuch Kuch Hota Hai'. Salman had a special appearance in the SRK-Kajol starrer.