The 3,158 square foot home was listed earlier this week with an asking price of USD 2,985,000, reported TMZ.
It was originally purchased by Thicke's father back in 1990 for a paltry USD 910,000.
The couple announced its separation in February, after nearly nine years of marriage.
The two-storey home overlooks the city's famous Sunset Boulevard, and includes a recording studio.
Thicke, 37, has made various public appeals to Patton over the past few months in a bid to win her back, and even titled his new album of love songs Paula, but it appears the actress wants no part of a reconciliation.