Trading was marked by volatility, with investors resorting to profit booking after yesterday's hefty gains.
Across the board selling was seen though pharma and shares of mid-cap companies witnessed buying.
Meanwhile, foreign institutional investors (FIIs) bought shares worth a net Rs 413.85 crore, as per provisional data from the stock exchange.
Bourses resumed lower on subdued Asian markets and fluctuated in range-bound trades amid choppiness during morning session. Trading hit negative zone and extended its afternoon losses to end in the red.
The 50-share Nifty traded between a high of 6,280.35 and a low of 6,234.15 before closing at 6,241.85, a loss of 30.90 points, or 0.49 per cent, over the previous close.
The major losers were Tata Steel, NMDC, DLF, Jindal Steel, Ranbaxy, ACC, TCS, Grasim, SSLT and Hindstan Uniliver, while CIPLA, Lupin, Cairn and IndusInd ended with gains.
Turnover in the cash segment fell to Rs 8,849.06 crore from Rs 10,528.28 crore yesterday. A total of 5,013.76 lakh shares changed hands in 49,54,256 trades, while market capitalisation stood at Rs 68,08,427 crore.