Macklemore, 30, and Lewis, 25, both from Seattle, won best new artist, following their phenomenal success with hits like 'Same Love', 'Can't Hold Us' and 'Thrift Shop' last night at LA's Staples Center.
They also bagged awards for best rap album, best rap performance and best rap song for 'Thrift Shop'.
"Wow, we're here on the stage right now. I want to say we made this album without a record label, we made it independently and we appreciate all the support," Macklemore said after receiving the awards.
They have been nominated for seven honours in total, including album of the year for 'The Heist'.
Grammys 2014 kicked off with a scintillating performance by Beyonce and Jay Z. The couple selected a duet-track from Beyonce's last album, 'Drunk in Love' for their performance.
A black lingerie-clad Beyonce, 32, started the show as she straddled a chair, surrounded by smoke. She sported a wet, chin-length hair and a smoky eye. She donned Saint Laurent tights, a custom bra, a Nicholas de Carle bodysuit, Stuart Weitzman shoes and Jennifer Fisher earrings.
Her husband then joined her onstage for his guest rap and got up close and personal with her as they performed the romantic, no-holds-barred track together.