The Netflix show's creator Jenji Kohan revealed that she was a fan of Holmes and considered the former 'Dawson's Creek' actress for the lead, reported E! online.
"You know, I met with her. She had other things to do. And also in the beginning, no-one knew what this was," Kohan said.
Taylor Schilling, who plays prisoner Piper, added, "I'm a big fan of Katie Holmes. She could be friends with Lorna or like Lorna's Boston sister."
Holmes has previously said that the Emmy-nominated show is one of her favourite series.