The mother-of-one said that she really missed being involved in the design process, and working with the team at the Arcadia Group chain, reported Hello! magazine.
"I have really missed being involved in the design process, and working with the team at Topshop. Now more than ever, with London being at the forefront of fashion... It feels like I'm back home working with Topshop," Moss said.
The 40-piece collection is infused with Moss' signature boho style.
Moss' collaboration with the high street retailer first began in 2007. She and Topshop boss Phillip Green had several sell-out collections before putting the partnership on hold in 2010.