Infosys said on Thursday Prasad Thrikutam, who was in charge of strategic sales, marketing and alliances, quit the company.
Infosys has lost at least 11 senior managers over the past year or so, as India's second-largest IT services exporter looks for a new chief executive.
Last month, president and board member B.G. Srinivas had quit.
Shares in Infosys were down 1.52 per cent at 0354 GMT.