Patton met Thicke when she was 15 and he was 14. They married more than a decade after that, in 2005, before announcing their separation earlier this year.
"We've known each other since we were teenagers. All I can tell you is there's a deep love there always was, and always will be," the actress, 38, told Vanity Fair.
"He wasn't my first kiss but he was my first lots of other things."
Thicke tried to win back Patton by making several public declarations of his love but it is not clear whether the couple is reuniting.