Couples may take longer to conceive a child when one or both partners has high cholesterol levels, according to a new study.
Cholesterol is a waxy, fat-like substance found in all cells of the body.
"In addition to raising the risk of cardiovascular disease, our findings suggest cholesterol may contribute to infertility," said one of the study's authors, Enrique F Schisterman, of the National Institutes of Health (NIH)'s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in Bethesda.
"Our results suggest prospective parents may want to have their cholesterol checked to ensure their levels are in an acceptable range," said Schisterman.
The population-based prospective cohort study examined the rate of pregnancies among 501 heterosexual couples trying to conceive.
The researchers enrolled 501 couples from four counties in Michigan and 12 counties in Texas from 2005 to 2009.
The couples were part of the Longitudinal Investigation of Fertility and the Environment (LIFE) study, established to examine the relationship between fertility and exposure to environmental chemicals and lifestyle.
Among the couples, 347 became pregnant over the course of the 12-month study. Fifty-four couples did not conceive a child.
Researchers measured each prospective parent's cholesterol by testing a blood sample taken at the study's outset.
Rather than measuring Low-density lipoprotein (LDL) cholesterol and other subtypes, the researchers measured the total and free amounts of cholesterol in the blood.
According to the findings, couples where one or both partners had high cholesterol took significantly longer to become pregnant.
"Couples in which both the prospective mother and father had high cholesterol levels took the longest time to conceive a child," Schisterman said.
"Our study also found couples in which the woman had high cholesterol and the man did not took longer to become pregnant than couples where both partners had cholesterol levels in the normal range," Schisterman said.
The study was published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).