The study adds evidence to previous reports suggesting an increased cardiac and cerebrovascular risk in children treated with growth hormone.
Researchers studied 6,874 children, average age 11, who were small for their age but otherwise generally healthy and were treated with growth hormone from 1985 to 1996. They followed them to an average age of 28.
There were 11 strokes in the group, four of them fatal. The analysis found that this was more than twice as many strokes as would be expected in a population this size, a statistically significant difference.
The results were published online in the journal Neurology.