The actor and his fiancee Amal Alamuddin, have been scouting venues in Italy for their big day in September, reported the New York Post.
The couple was seen dining in the floating city last month after touring possible wedding venues.
"George and Amal want to be married in Italy, but they need a location that offers them and their guests privacy," a source said.
Clooney, 53, also spent time in the city of love when he opened the 2013 Venice Film Festival with his and Sandra Bullocks Oscar-winning movie 'Gravity' and was spotted piloting a water taxi on the canals.
The recent celebrity to marry in Italy was reality star Kim Kardashian.