Researchers at The University of Texas Health Science Center at Houston divided parents into those who had more non-people-oriented jobs (technical) or more people-oriented jobs (non-technical).
Fathers who worked in engineering were two times as likely to have a child with an autism spectrum disorder (ASD).
Those who worked in finance were four times more likely and those who worked in health care occupations were six times more likely to have a child on the autism spectrum.
There was no association with a mother's occupation. However, children who had both parents in technical fields were at a higher risk of having a more severe form of autism.
"Parental occupation could be indicative of autistic-like behaviours and preferences and serve as another factor in a clinician's diagnosis of a child with suspected autism. Medical students can be taught that this is one of the things to consider," said Aisha S Dickerson, a researcher at UT Health's Center for Clinical and Translational Sciences.
The findings will be presented at the International Meeting for Autism Research in Atlanta.