According to the website downdetector.com, the outage began around 1600 GMT, and appeared to last less than an hour.
In that time, thousands of users complained they could not access the world's biggest social network.
Similar to the June incident, Facebook users took to Twitter to vent or post sardonic comments, many using the hashtag #facebookdown.
"Facebook is Down! Oh God! Now How the Hell Am I Going to Find Out How My Friends Feel About Facebook Being Down!" one user tweeted.
Another wrote "Facebook going down for 15 minutes is proof that today's generation wouldve survived approximately 8 seconds in the 80s."
A Twitter user with the handle @TheTweetofGod wrote, "#facebookdown. Please remain calm and do not attempt to interact with human beings."
During the outage, Facebook said in a statement, "We're aware that some people are currently having trouble accessing Facebook. We're working to get things back to normal as quickly as possible."