The 50-year-old actor collaborated with the website to offer this once-in-a-lifetime opportunity to 10 lucky fans across the world, reported E!Online.
Each contribution to the cause is an automatic entry into the contest to receive a memorable trip for two to New Orleans for the organization's gala on May 17.
Fans can purchase one of nine 'epic deals' for $25,000 each. The package includes all of the prizes, plus first-class airfare and hotel accommodations.
However, the Groupon website also said there is a possibility that people might not get a chance to meet Pitt.
"Meet-and-greet with Brad Pitt is contingent on the availability of all parties," Groupon wrote.