The 10th seeded Sania-Zheng pair had little trouble in defeating the current Wimbledon champions Su-Wei Hsieh of Taipei and Peng Shuai of China 6-4 7-6 in exactly an hour and 50 minutes to advance to the last four stage.
Sania and Zheng will meet eighth seeds -- Ashleigh Barty and Casey Dellacqua -- in the semi-final.
Sania and Zheng were quick to seize the initiative and a single break was enough to give them the opening set.
The second set went on serve before the Indo-Chinese combination secured a mini-break and held their serve thereafter to pocket the match.
For records, it will Sania's first semi-final appearance in the US Open and her fourth overall in a major tournament.
The Indian tennis ace has now reached the last four stage in the women's doubles at all the four major tournaments.