The state-run airline will operate a Boeing 787 Dreamliner in a two-class configuration - 18 business and 238 economy class seats - on the route.
These flights will be operated from Delhi to Leonardo da Vinci Airport in Rome and Malpensa Airport in Milan on a triangular route with a Boeing 787 Dreamliner, an Air India release said here.
While the Delhi-Rome-Milan-Delhi flight (AI-123) will operate on four days - Monday, Wednesday, Friday and Sundays - the Delhi-Milan-Rome-Delhi service will run on the other days of the week, it said.
By starting the maiden service to the key European country, Air India has fulfilled a long-standing demand of not only Indians residing in Italy but also the travel and tourism industry, the release said.
So far, passengers from India flying to these cities had to change to other airlines or transit at international hubs in West Asia.