The 37-year-old actress, who plays Leah Patterson-Baker, revealed earlier this year that she was due to give birth to her second child, reported Digital Spy.
A statement released to the media said: "Our baby boy Harrison was delivered stillborn on Thursday, August 7, 2014.
"We appreciate your love and support as we mourn the loss of our precious son. We understand we have lived some of our lives in the public eye, but we respectfully ask for privacy at this difficult and extremely painful time so we can grieve and heal."
Nicodemou married husband Chrys Xipolitas in 2007 and gave birth to her first son Jonas two years ago.
She has played 'Home and Away's Leah on-and-off since 2000.